The method, protocol describes a technique of how to introduce a double-stranded RNA (dsRNA) of choice into mouse oocytes or fertilized one-cell embryos by microinjection.  For collection of mouse oocytes and early embryos, see Collection of Mouse Oocytes for RNAi and Collection of Early Mouse Embryos for RNAi.

Protocol: Microinjection of dsRNA into Mouse Oocytes and Early Embryos Protocol